Small Molecule Purifications
Small Molecule Purification Services
At Rilas, we provide comprehensive small molecule purification services designed to support medicinal chemistry programs from early discovery through preclinical development. Our experienced purification scientists use advanced chromatographic platforms to isolate high-quality compounds from crude reaction mixtures, enabling researchers to move forward with reliable material for biological testing and further optimization.
Preparative HPLC Purification and Mass-Directed Chromatography
Our laboratory is equipped with automated preparative HPLC purification systems capable of handling a wide range of compound types and scales. Using mass directed preparative chromatography, fractions are collected based on real-time MS detection to ensure accurate isolation of the desired compound while minimizing impurities and byproducts.
This approach enables efficient purification of complex mixtures while delivering highly characterized material suitable for analytical characterization, screening, or further synthesis.
Custom Purification—Tailored purification strategies for each molecule
High Purity Material—Achieve purity levels suitable for screening or analytical characterization
Scalable Preparations—From milligram-scale discovery compounds to multi-gram quantities
Crude small molecule (left) to purified small molecule (right)
Why Choose Rilas for Small Molecule Purification?
Our expertise in small molecule purification ensures:
- Confidence in your data by removing impurities and delivering high-purity compounds.
- Faster decision-making with material that’s immediately ready for screening or further studies.
- Flexibility to handle challenging compounds, including highly polar, hydrophobic, or unstable molecules.
With advanced chromatographic platforms and experienced scientists, we provide reliable
purification solutions that support your discovery pipeline from hit-to-lead through preclinical
development.
Instrumentation:
Agilent 1290 Infinity II Mass Directed Automated Purification System