Peptide Purifications
Peptide Purification Services
Peptides present unique challenges compared to small molecules or libraryscale projects. Their diverse physicochemical properties — Including length, charge, solubility, and post-synthetic modifications — demand tailored purification strategies to ensure high recovery, purity, and consistency.
Our Approach
We combine state-of-the-art purification platforms with experienced scientists who understand the nuances of peptide chemistry. Each project is approached individually:
- Analytical evaluation of crude material.
- Iterative optimization for maximum yield and purity.
- Comprehensive QC to confirm identity, and purity.
Outcome: Reliable delivery of purified peptides tailored to your project’s requirements.
LC chromatograms of crude peptide LC (left) to purified peptide LC (right)
MS spectra of crude peptide (left) to purified peptide spectra (right).
Why Choose Rilas for Peptide Purification?
- Custom Purification Strategies
We adapt chromatographic techniques to each peptide’s chemistry. - High Purity Standards
Achieve >95% purity where required, suitable for bioassays, structural studies, or preclinical development. - Scalable Processes
From milligram discovery-scale preparations to gram-scale material for in vivo studies. - Handling Difficult Sequences:
Expertise with hydrophobic, highly charged, and modified peptides
Instrumentation:
Agilent 1290 Infinity II Mass Directed Automated Purification System