A World-Class Chemistry Laboratory Committed to Your Needs
Biomolecules
Antibodies / ADCs
- Glycosylation
- Sequencing
- Exact Mass
- Structural Characterization
Oligonucleotides
- QC analysis without ion pairing
- Structural characterization (2’, 3’, 4’)
- Exact mass
- Conjugate characterization
Peptides
- Sequencing
- Exact Mass
Proteins
- Glycosylation
- Sequencing
- Exact Mass
- Structural Characterization
Instrumentation
Agilent 6545XT AdvanceBio LC/Q-TOF
MOBILion MOBIE High Resolution Ion Mobility (HRIM)
Agilent 1260 Infinity II Bio-inert
Chiral SFC Separation
Preparative chiral separation from milligrams up to 50 g quantities of discovery research compounds, templates, intermediates, drug candidates
Enantiomeric and diastereomeric excess confirmation of starting materials, intermediates and final products
Automated method development for chiral separations
Absolute Configuration
Instrumentation
Agilent 1260 Infinity II SFC/MS
Waters SFC 80
BioTools Chiral R-2x
Buchi Rotavapors
Biotage V-10
HPLC/MS Purification
Achiral purification and reformatting mg to gram quantities of singletons and libraries of compounds
Automated method development for achiral separations
High-throughput HPLC/MS QC of compound collections up to 1000 compounds/week
Repeat literature analysis
Purity analysis by HPLC/MS
Sample Identification using LCMS
Reformatting in customer’s preferred format in up to four of the customer’s own barcoded vials
Instrumentation
Agilent 1290 Infinity II HPLC/MS
Agilent 1290 Infinity II Mass Directed Automated Purification System
TECAN Freedom Evo 150 Liquid Handler
Genevac EZ-2
Physico-Chemical Measurements
EPSA: SFC based measurement estimating the compounds’ polar surface area and its tendency of forming internal hydrogen bonds
Solubility: Measure peak area ratios relative to the peak in DMSO or methanol solution
Stability: Samples in aqueous solutions reanalyzed after 24 hours and compare to the original purity
LogD: Calculated based on retention time using a calibration curve generated by a shallow water/acetonitrile gradient
Glutathione Reactivity Measurement
Solubility and stability in simulated gastric solutions
Rilas can customize the measurements for any biologically relevant buffers customers require
Instrumentation
Agilent 1260 HPLC/UV/ELSD
TECAN Freedom Evo 150 Liquid Handler